Antioch was the administrative capital of the Roman province of Syria. With a population of half a million, it was also the third largest city in the empire, after Rome and Alexandria. As a busy cosmopolitan center, its racially mixed population was overwhelmingly gentile, but there was also a large Jewish community. At Antioch, for the first time, Jesus’ followers were called Christians. Originally, opponents of the church used the term as a derogatory label for the “devotees of the Anointed One” (in Greek, Christianoi ). But the believers soon adopted it gladly.