Aleyna: a mutation in Smchd1 was identified in the Momme screen. Smchd1 contains a SMC hinge domain present in proteins needed for chromosome condensation and cohesion but its function was otherwise unknown. identification in the screen suggested the involvement of cohesion-like proteins in epigenetic silencing (Blewitt et al., 2008). study of the mutant mice showed a role for Smchd1 in X-inactivation. female embryos homozygous for the Smchd1 null mutation died around mid-gestation, while male homozygotes survived for longer. in female homozygotes, a failure in silencing of genes on the inactive X-chromosome was accompanied by DNA hypomethylation (Blewitt et al., 2008).

a mutation in Smchd1 was identified in the Momme screen. Smchd1 contains a SMC hinge domain present in proteins needed for chromosome condensation and cohesion but its function was otherwise unknown. identification in the screen suggested the involvement of cohesion-like proteins in epigenetic silencing (Blewitt et al., 2008). study of the mutant mice showed a role for Smchd1 in X-inactivation. female embryos homozygous for the Smchd1 null mutation died around mid-gestation, while male homozygotes survived for longer. in female homozygotes, a failure in silencing of genes on the inactive X-chromosome was accompanied by DNA hypomethylation (Blewitt et al., 2008).

ikinci alıntı.Kitabı okudu

Epigenetics Brian P. Chadwick

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toska

@vkortk ·

11 Ocak 2021 01:27

ikinci 😌

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