Zilan: When an accessory receptor has a direct role in activating the T cell by generating its own intracellular signals, it is called a "co-receptor". The most important and best understood of the co-receptors on T cells are the CD4 and CD8 proteins, both of which are Single-Pass transmembrane proteins with extracellular Ig-like domains. Like TCRs, they recognize MHC proteins, but, unlike TCRs, they bind to invariant parts of the MHC protein, far away from the peptide-binding groove.

When an accessory receptor has a direct role in activating the T cell by generating its own intracellular signals, it is called a "co-receptor". The most important and best understood of the co-receptors on T cells are the CD4 and CD8 proteins, both of which are Single-Pass transmembrane proteins with extracellular Ig-like domains. Like TCRs, they recognize MHC proteins, but, unlike TCRs, they bind to invariant parts of the MHC protein, far away from the peptide-binding groove.

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Molecular Biology of the Cell Bruce Alberts

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