İdil Eylül Ünsal: "neutrophils and macrophages can kill bacteria": neutrophils and macrophages can kill bacteria ◦ Much of the killing effect results from several powerful oxidizing agents formed by enzymes in the membrane of the phagosome or by a special organelle called the peroxisome. These oxidizing agents include large quantities of superoxide (O2−), hydrogen peroxide (H2O2), and hydroxyl ions (OH−), which are lethal to most bacteria, even in small quantities. Also, one of the lysosomal enzymes, myeloperoxidase, catalyzes the reaction between H2O2 and chloride ions (Cl-) to form hypochlorite, which is exceedingly bactericidal.

◦ Much of the killing effect results from several powerful oxidizing agents formed by enzymes in the membrane of the phagosome or by a special organelle called the peroxisome. These oxidizing agents include large quantities of superoxide (O2−), hydrogen peroxide (H2O2), and hydroxyl ions (OH−), which are lethal to most bacteria, even in small quantities. Also, one of the lysosomal enzymes, myeloperoxidase, catalyzes the reaction between H2O2 and chloride ions (Cl-) to form hypochlorite, which is exceedingly bactericidal.

Kitabı okudu

Guyton and Hall Textbook of Medical Physiology John E. Hall

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