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We have a funny relationship with pleasure. We talk about simple pleasures or guilty pleasures, it's 'business or pleasure', but never the two together, and I've noticed that when we have a choice between pleasure or pain, we seem to think there's a worthiness in choosing pain.
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A study found that when we feel lonely, we lessen our inbuilt reflex to automatically mimic other people's smiles. Lonely people only reacted to signs of anger or sadness. When presented with faces showing joy, they didn't smile in response. The researchers aren't certain of the cause.
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