Major changes have taken place in our food supply to such an extent that current Western diets are not consistent with the diets humans evolved and to which our genes were programmed to respond. As an example, major changes have occurred in the production of oils from vegetables high in omega-6 fatty acids, as a result of the technology that made it possible to produce large amounts of oils from oil seeds such as corn, sunflower, safflower, soybean, cottonseed, etc. In addition to changes in the oils, there was a major change in animal feeds from eating grass (grazing) to grains high in omega 6 fatty acids. In the meantime, people ate less fish and more meat. Fish is high in omega-3 fatty acids, whereas meat from grainfed animals is high in omega-6 fatty acids. These changes led to a ratio of omega-6 to omega-3 of 20:1, whereas during evolution the ratio was 1:1. The imbalanced omega-6 to omega-3 ratio led to a proinflammatory diet. A high omega-6 to omega-3 ratio and a proinflammatory diet are at the base of all chronic diseases, also known as diseases of civilization.