The astronomer Carl Sagan used to say that understanding something does not diminish its wonder and mystery. Many people fear that scientific understanding entails a trade-off with wonder, as if knowledge leeches the flavor and color out of life. But Sagan was right. The truth is that, with understanding, we become more comfortable with our role in the universe and simultaneously the universe becomes even more colorful and mysterious. Being a tiny speck in an infinite cosmos, alive, aware, intelligent, and creative, is far more interesting than living on a flat, limited Earth at the center of a small universe. Understanding how our brains work does not diminish the wonder and mystery of the universe, our lives, or our future. Our amazement will only deepen as we apply this knowledge to understanding ourselves, building intelligent machines, and then acquiring more knowledge.