What keeps the immune system from successfully confronting the internal menace? This is where stress plays its incendiary role: for example, through the release of inflammatory proteins into the circulation -proteins that can instigate damage to DNA and impede DNA repair in the face of malignant transformation. These proteins, called cytokines, can also inactivate genes that would normally suppress tumor growth, enable chemical messengers that support the growth and survival of tumor cells, stimulate the branching of blood vessels that bring nutrients to feed the tumor, and undermine the immune system. Even at the cellular and molecular levels, the generation of ill health is a multifaceted, multistep process.