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Bloomberg Businessweek USA sözleri ve alıntılarını, Bloomberg Businessweek USA kitap alıntılarını, Bloomberg Businessweek USA en etkileyici cümleleri ve paragragları 1000Kitap'ta bulabilirsiniz.The poison is created by ranitidine itself.
The poison is created by ranitidine itself. Zantac’s makers and health regulators around the world recalled the drug, and in the spring of2020 the FDA forced it off the market altogether.
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In March 1988, Glaxo commissioned a Gallup Poll titled “Heartburn Across America,” It found 44% of the adult population suffered heartburn monthly. Zantac could be prescribed for heartburn by then, but plenty of antacids were available that didn’t require a prescription. Glaxo promoted the survey on television and in print. The ads noted that heartburn and other symptoms of chronic reflux could signal diseases such as ulcers and suggested seeing a physician.
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The analyst wrote that academic research in the US suggested that, under certain conditions in the stomach, ranitidine could form a potentially dangerous compound.
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For years, Glaxo counted on Zantac for nearly half of its sales and almost as much of its profit.
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Plaintiffs’ lawyer:
Plaintiffs’ lawyer: At any time when Zantac had been on the market for almost soyears, did Glaxo cause anyone to test for the presence of NDMA, a probable human carcinogen, in the product it was selling to American consumers known as Zantac?
Glaxo senior medical adviser: Not to my knowledge.
—Deposition, June 2021
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No company could manufacture it; nobody should ingest it. The carcinogen, called NDMA, was once added to rocket fuel and is now used only to induce cancer in lab rats.
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William Lijinsky was working as a cancer researcher for the US government in 1969 when he determined that nitrosamines could form in the stomach. Nitrites, a common chemical found in cured and grilled meat and in beer and coffee and vegetables, could combine with another group of chemicals called amines, compounds found in many medications. Acid in the stomach created the ideal environment for the reaction. The amount of nitrosamine created at one time might be insubstantial but over time could be dangerous. Lijinsky published studies about nitrosamines. He testified before Congress. He thought the easiest way to minimize the problem was to limit how much sodium nitrite food manufacturers could add to preserve and flavor meat. Ham, bacon, pastrami, corned beef, sausage: foods that, it turns out, are common causes of heartburn and acid reflux.
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They caused cancer in every species of animal tested. A single dose of less than a milligram of NDMA can mutate mice cells and stimulate tumors, and 2 grams can kill a person in days.
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Glaxo marketed it as better and safer than the drug that inspired it, Tagamet, and before long, Zantac overtook Tagamet to become the world’s bestselling prescription medication.
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Glaxo gave it the brand name Zantac.
The scientists had, as scientists sometimes do, looked for a way to mimic the success of an established drug-in this case, one that healed ulcers and could be used to treat heartburn.
They developed ranitidine quickly, and the US Food and Drug Administration reviewed it quickly. Glaxo gave it the brand name Zantac.
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