Epigenetics (Current Research and Emerging Trends)

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Adı:
Epigenetics
Alt başlık:
Current Research and Emerging Trends
Baskı tarihi:
9 Ocak 2015
Sayfa sayısı:
370
Format:
Karton kapak
ISBN:
9781910190074
Kitabın türü:
Dil:
İngilizce
Yayınevi:
Caister Academic Press
Epigenetics can have a significant impact on human health and disease susceptibility. Over the past few years, significant progress has occurred in this rapidly advancing field, and much key research has been published. This book has gathered together pioneers in the field of epigenetics to produce thought-provoking discussions on classic aspects of epigenetics and on the newer emerging areas. It includes topics on the impact of metabolism on the epigenome, how our actions may impact the health of our offspring several generations removed, and how exposure to environmental toxicants can have long-lasting effects on our epigenome with devastating consequences. This up-to-date volume is a major resource essential for those working in the field and is recommended reading for anyone new to this fascinating and fast-moving area of research.
Kitaba henüz inceleme eklenmedi.
a mutation in Smchd1 was identified in the Momme screen. Smchd1 contains a SMC hinge domain present in proteins needed for chromosome condensation and cohesion but its function was otherwise unknown. identification in the screen suggested the involvement of cohesion-like proteins in epigenetic silencing (Blewitt et al., 2008).

study of the mutant mice showed a role for Smchd1 in X-inactivation. female embryos homozygous for the Smchd1 null mutation died around mid-gestation, while male homozygotes survived for longer. in female homozygotes, a failure in silencing of genes on the inactive X-chromosome was accompanied by DNA hypomethylation (Blewitt et al., 2008).

Kitabın basım bilgileri

Adı:
Epigenetics
Alt başlık:
Current Research and Emerging Trends
Baskı tarihi:
9 Ocak 2015
Sayfa sayısı:
370
Format:
Karton kapak
ISBN:
9781910190074
Kitabın türü:
Dil:
İngilizce
Yayınevi:
Caister Academic Press
Epigenetics can have a significant impact on human health and disease susceptibility. Over the past few years, significant progress has occurred in this rapidly advancing field, and much key research has been published. This book has gathered together pioneers in the field of epigenetics to produce thought-provoking discussions on classic aspects of epigenetics and on the newer emerging areas. It includes topics on the impact of metabolism on the epigenome, how our actions may impact the health of our offspring several generations removed, and how exposure to environmental toxicants can have long-lasting effects on our epigenome with devastating consequences. This up-to-date volume is a major resource essential for those working in the field and is recommended reading for anyone new to this fascinating and fast-moving area of research.

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