Epigenetics Gönderileri
Epigenetics kitaplarını, Epigenetics sözleri ve alıntılarını, Epigenetics yazarlarını, Epigenetics yorumları ve incelemelerini 1000Kitap'ta bulabilirsiniz.
a mutation in Smchd1 was identified in the Momme screen. Smchd1 contains a SMC hinge domain present in proteins needed for chromosome condensation and cohesion but its function was otherwise unknown. identification in the screen suggested the involvement of cohesion-like proteins in epigenetic silencing (Blewitt et al., 2008).
study of the mutant mice showed a role for Smchd1 in X-inactivation. female embryos homozygous for the Smchd1 null mutation died around mid-gestation, while male homozygotes survived for longer. in female homozygotes, a failure in silencing of genes on the inactive X-chromosome was accompanied by DNA hypomethylation (Blewitt et al., 2008).
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