Zilan: More than four hundred years after Shakespeare so eloquently dramatized Hamlet's mental anguish, we can reconstruct what must have been going on in his brain -not with the Bard's magical language, but with a model of the brain under chronic stress. The architecture of the brain is literally remodeled under chronic stress. Hamlet didn't stand a chance. When his stress persisted, his cool system, specifically the prefrontal cortex, crucial for problem solving, and the hippocampus, important for memory, began to atrophy. Concurrently, his amygdala, at the core of the hot system, increased excessively in size. This combination of brain changes made self-control and cool thinking impossible. Further, as his stress continued long term, his amygdala went from hypertrophy to atrophy, ultimately preventing normal emotional reactions. No wonder Hamlet was a tragedy.

More than four hundred years after Shakespeare so eloquently dramatized Hamlet's mental anguish, we can reconstruct what must have been going on in his brain -not with the Bard's magical language, but with a model of the brain under chronic stress. The architecture of the brain is literally remodeled under chronic stress. Hamlet didn't stand a chance. When his stress persisted, his cool system, specifically the prefrontal cortex, crucial for problem solving, and the hippocampus, important for memory, began to atrophy. Concurrently, his amygdala, at the core of the hot system, increased excessively in size. This combination of brain changes made self-control and cool thinking impossible. Further, as his stress continued long term, his amygdala went from hypertrophy to atrophy, ultimately preventing normal emotional reactions. No wonder Hamlet was a tragedy.

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The Marshmallow Test Walter Mischel

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